Doctors have confirmed another death as a result of the H1N1 virus, also known as swine flu.
Chloe Lindsey, 14, of Tarrant County, Texas, died Sept. 27 after being sick for about five days.
Doctors also suspect the virus may have caused the death of Miami University freshman Matthew Healy, although they haven't confirmed it.
Meanwhile, federal officials say they are working as quickly as possible to secure vaccine supplies without cutting corners on safety.
The second wave of the swine flu is beginning to sweep across the country, leaving hospitals and schools scrambling to tackle the high volume of cases.
"H1N1 is spreading widely throughout the U.S.,'' Thomas Frieden, director of the federal Centers for Disease Control and Prevention, told the Washington Post.
Health facilities are reporting rapidly increasing numbers of patients suffering flu-like symptoms, according to the Post. "We're completely swamped," Ari Brown, an Austin, Texas pediatrician whose office had to call in extra nurses to handle the volume of patients, told the Post.
"It's been extraordinarily busy," he said. "We have a small parking lot to begin with. People now are circulating the neighborhood to try to find a place to park and the waiting room is completely packed."
At least 26 states are now reporting widespread flu activity, according to the CDC. That's up from 21 states a week earlier.
The Post reports 42 schools had to close in eight states Friday due to the flu, affecting more than 16,000 students.
Also, 91 percent of colleges are reporting cases of swine flu.
On the global front, the World Health Organization is reporting that the virus could affect as much as one third of the world's population.
Since swine flu vaccine producers will likely only be able to produce enough of the drug to cover one sixth of the global population, authorities are recommending schools and other gathering places practice vigilance, the Digital Journal reports.
Techniques for guarding against the flu include washing your hands, shielding your mouth when coughing and avoiding crowded areas.