Space Shuttle Endeavor blasted off toward the International Space Station early Monday.
The shuttle launched into orbit before dawn with five men and one woman on board in what is expected to be the shuttle program's last nighttime launch.
"Looks like the weather came together tonight," launch director Mike Leinbach told the astronauts right before liftoff. "It's time to go fly."
Commander George Zamka and his crew are expected to arrive at the space station early Wednesday.
The spacecraft is hauling a new room and observation deck. Crew members will team up with other station members to hook up the new station compartments.
NASA says this will be the last major construction job at the space station.