The debate is over and the candidates are back on the campaign trail trying to get an edge over the other.
Click on the video player to see Clinton and Obama counter each other's accusations.
According to new national poll numbers, Barack Obama is the frontrunner and he's picking up steam in Texas and Ohio ahead of next week's primaries.
Those races appear to be shaping up as "do or die" for Hillary Clinton.
They may have ended cordially, but during the debate the gloves came off and Clinton came swinging out of the gate.
"I just find it kind of curious that I keep getting the first question on all of these issues. But I'm happy to answer it," Clinton said.
Clinton first addressed last weekend's fiery remarks contesting what she called misleading information distributed by the Obama campaign.
"The choices that Senator Obama's campaign has made regarding flyers and mailers have been very disturbing to me," Clinton said.
Obama responded by saying, "Senator Clinton has, her campaign at least, has constantly sent out negative attacks on us and we haven't whined about it because I understand that's the nature of these campaigns."
The two sparred over health care, foreign policy, and changes they would make to NAFTA - a trade agreement negotiated under President Bill Clinton and reviled by critics as the reason for the loss of thousands of manufacturing jobs in industrial belt states like Ohio.
It's support from those blue collar workers that both presidential hopefuls need to win what's now seen as a crucial primary contest for the New York senator. She needs to win big to break Obama's momentum after 11 successive victories and her dwindling delegate support.
Trying to play up her experience, Clinton cast herself as better qualified to take on John McCain if he's the Republican nominee.
"Standing on that stage with Senator McCain, if he is, as appears to be, the nominee, I will have a much better case to make," Clinton said.
Obama disagreed that she has a better case to make.
"Having a debate with John McCain where your positions were essentially similar until you started running for President, does not put you in a strong position," he said.
This was their final debate ahead of the big races in Texas and Ohio.
Exactly who outperformed the other in the eyes of voters won't really be known until next week's primaries.