The U.S. House of Representatives approved a massive $1.1 trillion spending bill Thursday that boosts spending on domestic programs.

The 221 to 202 vote to pass the 1,088-page measure comes despite growing budget deficits. The bill combines $447 billion in operating budgets with approximately $650 billion for federal programs such as Medicare and Medicaid.

In the 2009 budget year, the deficit was $1.4 trillion. A similar figure is expected for 2010.

"When are we going to say, 'Enough is enough?'" asked House GOP Leader John Boehner of Ohio. "Let's stop the madness."

The Democrats, however, remain unapologetic.

"I see these bills as an opportunity to reverse years of neglect - neglect to our roads and bridges, neglect to our lower-income neighbors and friends, neglect to our education system, neglect to our veterans," Rep. Jim McGovern, D-Mass. said.

The Senate is expected to vote on the bill this weekend before sending it to President Obama for his signature.