A powerful tornado that struck after dark killed at least two people in a small Oklahoma town, the Medical Examiner's Office confirmed.

Emergency Management officials said the main highway through the area was not passable because of uprooted trees and overturned tractor trailer trucks.

One resident of Tuska, located about 120 miles southeast of Oklahoma City, said it "felt like a bomb," The Associated Press reported.

"Everything in my house looks like shambles," Jennifer Buffington, 36, said. She, her husband and seven children took refuge in a neighbor's storm cellar when the siren sounded. When the storm passed, the family spent the night in the First Baptist Church in Atoka.

About two dozen people were treated for injuries, some serious, according to early reports.

Authorities issued tornado warnings along a 100-mile area of southeastern Oklahoma as the storm moved along an east-northeastern path. Earlier, the same storm cell prompted tornado watches in Arkansas, Kansas, Missouri and Oklahoma.