Forecasters say two storms -- one coming from the Great Lakes and the second moving up the East Coast -- may converge over New England on Friday, dumping up to two feet of snow in the region.
Parts of Massachusetts and Rhode Island are under a blizzard watch.
"Friday afternoon is going be a real nightmare," meteorologist Mark Rosenthal told Boston TV station WBUR.
"Snow's going to be falling at a pretty good clip, the winds are going to be picking up from the Northeast at 30 to 50 miles per hour, and the worst part of the storm, I believe, will be Friday night through much of Saturday," he said.
Travel may become hazardous because of high winds and blowing snow, and a coastal flood watch is in effect for some shore communities.
Meanwhile, ski resorts in the area are excited about the prospect of the first major snowstorm since 2011.