President Barack Obama, Mexican President Felipe Calderon and Canadian Prime Minister Stephen Harper are meeting in Guadalajara, Mexico, Monday, for day two of the North American leader's summit.
The president's summit with the Mexican and Canadian leaders marks his first three-way meeting with the America's closest neighbors.
Topping the summit's agenda will be the swine flu outbreak, which started in Mexico and is now considered a global pandemic
"I think everybody recognizes that H1N1 is going to be a challenge for all of us and there are people who are going to be getting sick in the fall and die," said John Brennan, Homeland Security Advisor.
Beyond the conversation about swine flu, there is also an unsettled trucking dispute between the U.S. and Mexico.
In the spring, President Obama signed a bill blocking Mexican trucks from entering the U.S., because of safety concerns. In return, Mexico imposed more than $2 billion of tariffs on U.S. goods.
It has put a strain on America's trade relationship with Mexico.
"Allowing Mexican long-haul trucking into our country is going to diminish safety on our highways," said Sen. Byron Dorgan, D-N.D.
The other safety concern on the agenda is drug trafficking. The violence leads to dozens of killings in Mexico each month, and drug cartels are spreading north into the U.S.
"We have responsibilities to reduce the trafficking of guns into the south that help strengthen these cartels," Obama said.
The meeting wraps up Monday afternoon.