Libyan leader Moammar Gadhafi survived a NATO airstrike that killed his youngest son and three of his grandchildren, a government spokesman said on Saturday.

Gadhafi and his second wife, Safiya Farkash, were visiting Seif al-Arab, 29, the youngest of Gadhafi's seven sons, when at least three missiles struck his son's home in Tripoli, government spokesman Moussa Ibrahim told reporters.

"The leader himself is in good health. He was not harmed. The wife is also in good health," Ibrahim said at a press conference.

Seif al-Arab "was playing and talking with his father and mother and his nieces and nephews and other visitors when he was attacked for no crimes committed," Ibrahim said.

"What we have now is the law of the jungle," Mussa Ibrahim told reporters. "We think now it is clear to everyone that what is happening in Libya has nothing to do with protection of civilians," he said.

In the western city of Misrata, where random shelling by Gadhafi's forces have killed hundreds, rebel forces drove through the streets honking horns and shouting "Allahu Akbar" (Allah is greater).

Saturday's attack marked the first NATO airstrike directly targeting the Gadhafi family.

In a pre-dawn speech Saturday, Gadhafi called for an end to NATO's six-week bombing campaign and a ceasefire with rebel forces.

But rebel leaders rejected the ceasefire, calling it a publicity stunt and vowing not to negotiate until Gadhafi and his son, Seif al-Islam, step down.

Rebel spokesman Jalal al-Galal said the situation was "well past any discussions."

"We don't believe there is a solution that includes him or any member of his family," al-Galal said. "The only solution is for him to depart," he said.

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Reuters and AP contributed to this report.