President Barack Obama met Wednesday with Pakistani Prime Minister Nawaz Sharif. Tensions are high between the two countries because of U.S. drone strikes against terrorists in the region.
Pakistan is calling on the United States to put an end to the attacks.
"This issue has become a major irritant in our bilateral relationship (with the United States) as well," Nawaz said. "I would, therefore, stress the need for an end to drone attacks."
The prime minister's visit to the White House comes one day after Amnesty International released a report providing new details about the alleged victims of U.S. drone attacks in Pakistan, one of them a 68-year-old grandmother hit while farming with her grandchildren.
In Pakistan, there is widespread belief that American drone strikes kill large numbers of civilians and Sharif is expected to raise the issue with Obama.
The White House responded to the Amnesty report by defending the drone program, with White House press secretary Jay Carney saying U.S. counterterrorism operations "are precise, they are lawful and they are effective."
Tensions escalated after the 2011 U.S. strike within Pakistan that killed Osama bin Laden and last year's accidental killing of two dozen Pakistani troops in an American airstrike along the Afghan border.